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-synuclein, that's a main component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) stress, recommend that dysfunction of the intracellular proteinase systems, like ubiquitin-proteasome technique or lysosomal procedure, which gets rid of needless harmful pro